Discovering in vitro spermatogenesis stimulating factors
نویسندگان
چکیده
منابع مشابه
In vitro spermatogenesis
The generation of functional sperm in vitro has been a goal for almost a century. Until recently, researchers have only succeeded in reproducing the early steps of spermatogenesis. This is not surprising given that spermatogenesis is a complicated process that requires the coordinated efforts of germ cells and several somatic cells within the tubular structure of the testis. Finally-last year-S...
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The role of follicle-stimulating hormone (FSH) in the control of spermatogenesis is not well established in any species, including man. We studied the effect of an experimentally-induced, selective FSH deficiency on sperm production in normal men. After a 3-mo control period, five normal men received testosterone enanthate (T) 200 mg i. m. weekly to suppress luteinizing hormone (LH) and FSH, un...
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Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation process is more or less completely dependent upon the cells being located within the strongly structured niche provided by mature...
متن کاملThe expression of the follicle-stimulating hormone receptor in spermatogenesis.
Results from experiments using mouse models suggest that the role of follicle-stimulating hormone (FSH) in spermatogenesis is the regulation of Sertoli cell proliferation and, ultimately, the size and spermatogenic capacity of the testis. The regulation of the expression of the FSH receptor (FSHR) gene is very cell specific and plays an initial role in the ultimate response of the Sertoli cells...
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By WENDELL F. RossE, THOMAS WALDMANN AND ELEANOR Huu. H YPOXIA AND ANEMIA have been known for many years to stimulate erythropoiesis in mammals, including man.1 In recent years, these stimuli have been shown to have their effect through a humoral factor, erythropoietin.2 J acobson, et al. have suggested that lack of oxygen, relative to the metabolic needs of the animal, is the fundamental stimu...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2015
ISSN: 2041-4889
DOI: 10.1038/cddis.2015.303